| 随机扰动下DNA三核苷酸重复序列的弯曲和柔性 |
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| 引用本文： | 贾孟文,蔡禄.随机扰动下DNA三核苷酸重复序列的弯曲和柔性[J].内蒙古大学学报(自然科学版),2001,32(2):161-168. |
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| 作者姓名： | 贾孟文 蔡禄 |
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| 作者单位： | [1]内蒙古大学物理学系、理论生物物理研究室，内蒙古呼和浩特010021 [2]包头钢铁学院生物与化学工程系，内蒙古包头 |
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| 基金项目： | 内蒙古自然科学基金资助项目 |
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| 摘 要： | 利用统计力学模型讨论了与人类遗传病有关的DNA三核苷酸重复序列的弯曲和柔性，提出随机成动模型来近似表示DNA序列和蛋白质的相互作用，发现弯曲很小的三核苷重复序列在有随机扰动的情况下，可以出现大角度的弯曲，且随扰动强度的加大出现大角度弯曲的概率增加，求出了十二种三核苷重复序列的柔性及其长度依赖，发现当序列长度大于150 bp时，柔性的变化开始显，CTG和CGG具有最大的柔性，研究了柔性在有随机扰动时下的变化，发现在序列上不同位置施加扰动，柔性的变化程度不同，对于600bp长的序列，在390bp处的柔性变化程度最大。
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| 关 键 词： | 随机成动 弯曲 柔性 DNA三核苷酸重复序列 统计力学模型 弯曲角度 扰动强度 |
| 文章编号： | 1000-1638(2001)02-0161-08 |
| 修稿时间： | 2000年7月3日 |
Bending and Flexibility of Trinucleotide Repeat Sequence in Stochastic Disturbing Model |
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| JIA Meng wen ,Tsai Lu.Bending and Flexibility of Trinucleotide Repeat Sequence in Stochastic Disturbing Model[J].Acta Scientiarum Naturalium Universitatis Neimongol,2001,32(2):161-168. |
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| Authors: | JIA Meng wen Tsai Lu |
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| Institution: | JIA Meng wen 1,Tsai Lu 1,2 |
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| Abstract: | We use a statistical mechanical model to discuss bending and flexibility of trinucleotide repeat sequences (TRS) which associate with several human genetic diseases. The stochastic disturb model is proposed to represent the events of DNA sequence interacted with a proteins. We found that the bending angle of trinucleotide repeat sequences has the property that the probability of appearance of large bending angle increase with strength and width of stochastic disturb while the sequences is nearly straight in free case. The average flexibility of TRS has small difference between free case and stochastic disturb case. But the flexibility changes obviously with the position where the stochastic disturb is exerted. |
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| Keywords: | stochastic disturb TRS bending flexibility |
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