Erythropoietins from teleosts |
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| Authors: | C-Y Chu C-H Cheng C-H Yang C-J Huang |
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| Institution: | (1) Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei, 106, Taiwan;(2) Institute of Biological Chemistry, Academia Sinica, Taipei, 115, Taiwan;(3) Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan |
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| Abstract: | The epo genes of many teleosts, including zebrafish, have been cloned following the first identification of nonmammalian EPO
from fugu in 2004. The zebrafish (Danio rerio) animal model is well suited for both developmental and genetic analyses for
studying vertebrate erythropoiesis. The purpose of this review is to provide an update of recent progress in research on teleost
EPO with a focus on its structure, expression and secretion. The EPO receptor and the downstream JAK/STAT signaling pathway
are also discussed.
Received 29 April 2008; received after revision 23 June 2008; accepted 25 June 2008 |
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| Keywords: | " target="_blank"> EPO EPO receptor glycosylation secretion zebrafish |
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