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Effect of sulfated and non-sulfated gastrin and octapeptide-cholecystokinin on cat gall bladder in vitro |
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| Authors: | J. R. Chowdhury J. M. Berkowitz M. Praissman J. W. Fara |
| Affiliation: | (1) Department of Physiology and Biophysics, State University of New York at Stony Brook, 11794 Stony Brook, N. Y., USA;(2) Department Medicine, State University of New York at Stony Brook, 11794 Stony Brook, N. Y., USA;(3) Division of Gastroenterology, Nassau Conty Medical Center, 11554 East Meadow, N. Y., USA;(4) Present address: Dept. of Medicine, Division of Gastroenterology, Albert Einstein College of Medicine, Bronx, N. Y., USA |
| Abstract: | Summary This study demonstrates that for the isolated cat gall bladder a smaller molar dose of the sulfated form of OP-CCK and gastrin is required to produce contraction as compared to the respective non-sulfated forms. For OP the D50 for the sulfated form versus the non-sulfated form was 1.94. For gastrin it was 1.10.This study was supported in part from NIH grant No. HL 15422 from the National Heart and Lung Institute. |
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