冠心病维医证型与血栓前状态分子标志物的关系

 为探讨冠心病患者维医证型与血栓前状态分子标志物的关系,随机选取住院治疗的冠心病患者245例,按照维医理论进行分型,并采用流式细胞术、放射免疫法和ELISA方法检测各分型患者外周血中血小板膜糖蛋白(CD41)、血小板活化标志物P-选择素(CD62p)的表达水平及内皮素-1(ET-1)、组织性纤溶酶原激活剂(t-PA)、组织性纤溶酶原抑制剂(PAI)、纤维蛋白原(FIB)、活化部分凝血活酶时间(PT)、凝血酶时间(TT)、血浆凝血酶原时间(APTT)水平.与正常对照组相比,异常黑胆质型冠心病组和非异常黑胆质(异常血液质、异常黏液质、异常胆液质)型冠心病组CD62p、FIB、PAI、ET-1水平升高(P<0.05),t-PA水平降低(P<0.05),PT、APTT时间缩短(P<0.05),而CD41、TT在各组间比较无差异(P>0.05);异常黑胆质型冠心病组与异常血液质型冠心病组及异常胆液质型冠心病组相比,ET-1水平升高(P<0.05);与异常黏液质型冠心病组相比,CD62p阳性百分数增多(P<0.05);而CD41阳性百分数、t-PA及PAI-1含量、PT、TT和APTT在各型冠心病组之间无差异(P>0.05).各异常体液型冠心病患者均存在不同程度的血栓前状态改变,表现为血管内皮细胞损伤、血小板活化、血液黏度增高、纤溶功能降低,且以异常黑胆质型冠心病患者变化较为明显.

Relationship Between Changes of Prethrombotic State with Coronary Heart Diseases and Traditional Urgur Medicine Syndromes

To investigate the relationship between changes of prethrombotic state with coronary heart diseases and traditional Urgur medicine syndromes on coronary heart diseases. 245 patients with coronary heart diseases were randomly selected and then grouped according to the traditional Urgur medicine theories. The expression of CD62p on platelets, the level of plasma tissue Plasminogen Activator (t-PA), the level of Serum Endothelin (ET-1), the Activated Partial Thromboplastin Time (APTT), the Fibrinogen (FIB), the Nprothrombin Time(PT), and the Thrombin Time(TT) were determined by flow cytometer, enzyme-linked immunosorbnent assay,radioimmunoassay method, and auto coagulometer. Compared to the control group, the levels of CD62p, FIB, PAI and ET-1 are increased in the abnormal savda group and the non-abnormal savda(abnormal khan, abnormal sepra and abnormal belghem)group (P<0.05); the level of t-PA is decreased in the abnormal savda group and the non-abnormal savda group (P<0.05); the APTT and PT are shortened in the abnormal savda group and the non-abnormal savda group (P<0.05), There are no significant changes of CD41 and TT in all groups (P>0.05). Compared to the abnormal savda group, the level of ET-1 is increased in the abnormal khan and abnormal sepra group(P<0.05), the level of CD62p is increased in the abnormal belghem group(P<0.05),there are no significant differences of the levels of CD41, t-PA, PAI-1, PT, TT and APTT in patients with different traditional Urgur medicine syndrome groups (P>0.05). There is the prethromboitic state in all different Urgur abnormal syndrome groups of coronary heart diseases, which can be observed in the injury of vessel epithelial cells, increased platelet activity, increased blood viscosity, decreased fibronolytic function. The prethromboitic state of the abnormal savda syndrome group with coronary heart diseases is more obvious than other abnormal syndrome groups.