Pyruvate kinase inhibited by L-cysteine as a marker of tumorigenic human urothelial cell lines |
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| Authors: | M. Gumińska M. B. Stachurska B. Christensen V. Tromholt J. Kieler Cz. Radzikowski D. Duś |
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| Affiliation: | (1) Institute of Medical Biochemistry, N. Copernicus Academy of Medicine, Kopernika 7, 31-034 Kraków, Poland;(2) The Fibiger Institute, Danish Cancer Society, Ndr. Frihavnsgade 70, DK-2100 Copenhagen Ø, Denmark;(3) Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Czerska 12, 53-114 Wroclaw, Poland |
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| Abstract: | Summary It was found that a decrease in electrophoretic mobility of pyruvate kinase (PK) isoenzyme, and an increase of the sensitivity of this enzyme to L-cysteine, were markers of immortalization and tumorigenic properties, respectively, in human urothelial cell lines characterized by different grades of transformation (TGr) in vitro. |
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| Keywords: | Pyruvate kinase human urothelial cell lines L-cysteine tumor marker |
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