The multiple roles of monocyte subsets in steady state and inflammation |
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Authors: | Clinton S Robbins Filip K Swirski |
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Institution: | (1) Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Simches Research Building, 185 Cambridge St., Boston, MA 02114, USA; |
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Abstract: | Monocytes participate importantly in immunity. Produced in the bone marrow and released into the blood, they circulate in
blood or reside in a spleen reservoir before entering tissue and giving rise to macrophages or dendritic cells. Monocytes
are more than transitional cells that adapt to a particular tissue environment indiscriminately. Accumulating evidence now
indicates that monocytes are heterogeneous in several species and are themselves predetermined for particular function in
the steady state and inflammation. Future therapeutics may harness this heterogeneity to target harmful functions while sparing
those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in
humans and mice. |
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Keywords: | |
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