| 镉盐及镉与锌联合应用对lewis肺癌小鼠的影响 |
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| 引用本文： | 李岩,张祥,付婷钰,李薇.镉盐及镉与锌联合应用对lewis肺癌小鼠的影响[J].北京理工大学学报,2015,35(S1):153-155,159. |
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| 作者姓名： | 李岩 张祥 付婷钰 李薇 |
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| 作者单位： | 北京理工大学 生命学院, 北京 100081,北京理工大学 生命学院, 北京 100081,北京理工大学 生命学院, 北京 100081,吉林大学 第一医院肿瘤中心, 吉林, 长春 130021 |
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| 摘 要： | 探讨4种镉盐对lewis肺癌的作用,以及锌与镉联合应用时锌的保护机制.建立lewis肺癌小鼠模型,随机分成不同的给药组.16 d后检测瘤重、胸腺指数、脾脏指数以及肝脏和肿瘤中的金属硫蛋白含量.氯化镉组对lewis肺癌抑制作用明显并可以增强荷瘤小鼠的免疫功能.1 mg·kg-1氯化镉组与联合应用组相比肿瘤抑制率无显著性差异,而且后者小鼠肝脏中MT表达量显著增加.结果表明氯化镉可有效抑制lewis肺癌细胞的增殖,最佳抑制剂量为1 mg·kg-1;在联合应用组中,氯化锌在不影响镉抗lewis肺癌效果的同时还能够进一步减轻镉对机体正常组织的毒性作用.
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| 关 键 词： | 氯化镉 lewis肺癌 金属硫蛋白 |
| 收稿时间： | 2015/3/20 0:00:00 |
Effects of Cadmium Salt and Cadmium Combined with Zinc on Lewis Lung Carcinoma in Mice |
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| LI Yan,ZHANG Xiang,FU Ting-yu and LI Wei.Effects of Cadmium Salt and Cadmium Combined with Zinc on Lewis Lung Carcinoma in Mice[J].Journal of Beijing Institute of Technology(Natural Science Edition),2015,35(S1):153-155,159. |
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| Authors: | LI Yan ZHANG Xiang FU Ting-yu and LI Wei |
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| Institution: | School of Life Science, Beijing Institute of Technology, Beijing 100081, China,School of Life Science, Beijing Institute of Technology, Beijing 100081, China,School of Life Science, Beijing Institute of Technology, Beijing 100081, China and Cancer Center, First Affiliated Hospital, Jilin University, Changchun, Jilin 130021, China |
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| Abstract: | To evaluate the effects of four kinds of cadmium salts on C57BL/6 mice implanted with lewis lung carcinoma(LLC), and further investigate the protective mechanism of zinc(Zn). C57BL/6 mice inoculated with LLC were randomly grouped for different drug administration. After 16 days, tumor weight, index of spleen and thymus, and metallothionein (MT) expression were evaluated. CdCl2 showed significant anti-tumor effects on LLC and could enhance the immune function of mice. The tumor inhibitory rate between CdCl2(1 mg·kg-1) and Cd+Zn group showed no significant difference. Compared with CdCl2(1 mg·kg-1), MT expression of Cd+Zn group showed a significant increase in liver.In conclusion, CdCl2 has a significant inhibitory effect on LLC. The most favorable dosage of CdCl2 is 1 mg·kg-1. Pretreatment with Zn has protective effects on hepatic cells, and it causes no significant difference about the inhibition effects of CdCl2 on LLC cells. |
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| Keywords: | cadmium chloride lewis lung carcinoma metallothionein |
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