Effects of acetaldehyde and/or ethanol on neutral amino acid transport systems in microvillous brush border membrane vesicles prepared from human placenta |
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| Authors: | M Asai O Narita S Kashiwamata |
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| Institution: | (1) Department of Obstetrics and Gynecology, Nagoya University Branch Hospital, Higashi-ku, 461 Nagoya, Japan;(2) Department of Perinatology, Institute for Developmental Research, Aichi Prefecture Colony, 480-03 Kasugai, Aichi, Japan |
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| Abstract: | Summary At 20 mM of acetaldehyde, the activities of three transport systems of L-alanine distinguished by the difference in their cation dependence, namely 1) Na+-specific, 2) Li+-dependent, and 3) Na+-independent systems, were significantly reduced in a similar manner. Only the Li+-dependent system was selectively inhibited at toxic concentrations of acetaldehyde and ethanol. |
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| Keywords: | L-Alanine transport system membrane vesicle human placenta acetaldehyde ethanol |
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