定喘颗粒止咳平喘作用研究

摘要: 目的研究定喘颗粒的止咳平喘作用，为其临床应用提供药理学依据。方法采用豚鼠离体气管条法、乙酰胆碱和磷酸组胺混合液致豚鼠哮喘、二氧化硫引咳小鼠和拘橼酸引咳豚鼠等模型，观察定喘颗粒的止咳平喘作用。结果定喘颗粒能明显抑制磷酸组胺、乙酰胆碱所致豚鼠离体气管条收缩，显著延长豚鼠哮喘潜伏期以及减少小鼠和豚鼠的咳嗽次数。结论定喘颗粒具有明显的止咳平喘作用。

A Study on Antitussive and Antiasthmatic Actions of Ding-chuan Granule

Abstract: Objective To investigate antitussive and antiasthmatic actions of Ding-chuan granule for providingtheory evidence of its clinic use． Method Histamine and acetylcholine were used to induce tracheospasm in wholebody and guinea pig's isolated trachea test，tussive models induced by SO2 in mice，cough model induced by citricacid in guinea pigs were used to obverse the antitussive and antiashmatic action of Ding-chuan granule． ResultThe result showed that Ding-chuan granule markedly reduced the contraction amplitude of isolated trachea induced byhistamine and acetylcholine in the guinea pig and markedly prolonged the latent period of asthmatic attack induced bymixture of histamine-acetylcholine in guinea pig and decreased the frequency of cough induced by citric acid inguinea pigs and SO2 in mice． Conclussion Ding-chuan granule has the antitussive and antiasthmatic actions．