| 吡唑并嘧啶衍生物的合成及其生物活性研究 |
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| 引用本文： | 陆涛,汪雨潇.吡唑并嘧啶衍生物的合成及其生物活性研究[J].江西师范大学学报(自然科学版),2011,35(1):10-14. |
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| 作者姓名： | 陆涛 汪雨潇 |
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| 作者单位： | 中国药科大学江苏省新药筛选中心,江苏,南京,211198 |
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| 摘 要： | 设计合成了新型吡唑并嘧啶衍生物3,6-二烷硫基-1-苯基-吡唑并3,4-d]嘧啶-4-酮的6个衍生物,其中4个获得大于70%的产率.应用1H NMR和IR对其结构进行了分析与确证.对所合成的产物进行了初步的除草活性试验,在质量分数为1×10-4时,合成产物对稗草的茎、油菜的根茎都显出较好的抑制作用.
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| 关 键 词： | 吡唑并嘧啶 氮杂Witting反应 除草剂 生物活性 |
The Study on Synthesis and Biological Activity of Pyrazolopyrimidine Derivatives |
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| LU Tao,WANG Yu-xiao.The Study on Synthesis and Biological Activity of Pyrazolopyrimidine Derivatives[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2011,35(1):10-14. |
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| Authors: | LU Tao WANG Yu-xiao |
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| Institution: | LU Tao,WANG Yu-xiao(Basic Pharmacy,China Pharmaceutical University,Nanjing Jiangsu 211198,China) |
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| Abstract: | A series of derivatives of a new pyrazolopyrimidine,3,6-dialkylthiol-1-phenyl-pyrazolo 3,4-d]pyrimidin-4-one were synthesized,four of which showed yield larger than 70%.The structure of products were analyzed and confirmedby method of 1H NMR and IR.Experiment on herbicidal activity showed that the products considerably inhibited growth of stalk of barnyard grass and both root and stalk of cole. |
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| Keywords: | pyrazolopyrimidine Aza-witting reaction herbicide biological activity |
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