Injury-induced neurogenesis in the mammalian forebrain |
| |
Authors: | Email author" target="_blank">Koji?OhiraEmail author |
| |
Institution: | (1) Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake Aichi, 470-1192, Japan |
| |
Abstract: | It has been accepted that new neurons are added to the olfactory bulb and the hippocampal dentate gyrus throughout life in
the healthy adult mammalian brain. Recent studies have clarified that brain insult raises the proliferation of neural stem
cells/neural progenitor cells existing in the subventricular zone and the subgranular zone, which become sources of new neurons
for the olfactory bulb and the dentate gyrus, respectively. Interestingly, convincing data has shown that brain insult invokes
neurogenesis in various brain regions, such as the hippocampal cornu ammonis region, striatum, and cortex. These reports suggest
that neural stem cells/neural progenitor cells, which can be activated by brain injury, might be broadly located in the adult
brain or that new neurons may migrate widely from the neurogenic regions. This review focuses on brain insult-induced neurogenesis
in the mammalian forebrain, especially in the neocortex. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|