Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections |
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Authors: | N Mookherjee R E W Hancock |
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Institution: | (1) Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada |
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Abstract: | An increase in antibiotic resistance and the emergence of new pathogens has led to an urgent need for alternative approaches
to infection management. Immunomodulatory molecules that do not target the pathogen directly, but rather selectively enhance
and/or alter host defence mechanisms, are attractive candidates for therapeutic development. Natural cationic host defence
peptides represent lead molecules that boost innate immune responses and selectively modulate pathogen-induced inflammatory
responses. This review discusses recent evidence exploring the mechanisms of cationic host defence peptides as innate immune
regulators, their role in the interface of innate and adaptive immunity, and their potential application as beneficial therapeutics
in overcoming infectious diseases.
Received 3 November 2006; received after revision 14 December 2006; accepted 22 January 2007 |
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Keywords: | Innate immunity inflammation host defence |
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