Effects of a new cholecystokinin antagonist (GE 410) on the smooth muscle of the guinea pig ileum |
| |
| Authors: | A Rakovska K Milenov P Henklein |
| |
| Institution: | (1) Institute of Physiology, Bulgarian Academy of Sciences, Acad. G. Bonchev St., bl. 23, B-1113 Sofia, Bulgaria;(2) Institute of Pharmacology and Toxicology, Humboldt-University Berlin, DDR-1040 Berlin, German Democratic Republic |
| |
| Abstract: | Summary Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp- -phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA2=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the 3H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the 3H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons. |
| |
| Keywords: | Cholecystokinin octapeptide cholecystokinin antagonist (GE 410) [3H]ACh release ileac smooth muscle |
| 本文献已被 SpringerLink 等数据库收录！ |
|
