Neuronal responses to extracellularly applied cyclic AMP: Role of the adenosine receptor |
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| Authors: | D. A. Taylor T. W. Stone |
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| Affiliation: | (1) Laboratory of Neuropharmacology, N.I.M.H., St. Elizabeth's Hospital, Washington D.C., USA;(2) Department of Physiology, University of Aberdeen, (Scotland);(3) Present address: Department of Pharmacology, University of Colorado Medical Centre, 80222 Denver, Co., USA;(4) Present address: Department of Physiology, St. George's Hospital Medical School, University of London, SW17ORE London, England |
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| Abstract: | ![]()
Summary At low doses, theophylline blocks the neuronal depressant effects of 5 -AMP, but not cyclic AMP. Higher doses (100 mg/kg) block cyclic AMP responses and reduce the effects of noradrenaline and GABA. It is concluded that cyclic AMP does not depress neurones via the adenosine receptor.We are grateful to the Wellcome Trust and Royal Society for travel grants. |
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