Melkersson-Rosenthal综合征3例临床分析

Melkersson-Rosenthal综合征，是一种罕见的神经，皮肤粘膜综合征，临床以间歇性面瘫，再发性唇面肿胀及皱襞舌为三主症，激素治疗有显著疗效，但国内报道极少，早期诊断困难，易被诊，本文报道我院近十年来收治的3例完全型MRS病人及随访资料，结合国内外文献，就其病因，发病机制，临床特征及近年来研究进展进行分析，认为该病发病机理可能与免疫功能异常所致组织炎性肉芽肿有关。

Melkersson-Rosenthal syndrome

Melkersson-Rosenthal syndrome (MRS) is a rare disorder of unknown etiology,with the clinical manifestation of recurrent lip and/or face swelling,fissured tongue,and intermittent peripheral facial palsy.It can be effectively treated with glucocorticosteroids.This syndrome is hard to be correctly diagnosed in the early stage.We report three definite MRS cases in our hospital from 1991 to 2000 and discuss its causes,pathogenesis and clinical features by reference to recent lite ature.It has been concluded that immune dysfunction might participate in the pathogenesis of this syndrome,and pathologically is a granuloma.