| 无机砷化合物对人血淋巴细胞分裂和DNA合成的效应 |
| |
| 引用本文： | 孟紫强,高昆.无机砷化合物对人血淋巴细胞分裂和DNA合成的效应[J].山西大学学报(自然科学版),1993,16(4):467-473. |
| |
| 作者姓名： | 孟紫强 高昆 |
| |
| 作者单位： | 山西大学环境科学系，山西大学环境科学系，山西大学环境科学系 89级毕业生，89级毕业生 |
| |
| 摘 要： | 本研究指出,低浓度的三氧化二砷、亚砷酸钠及砷酸钠对植物血凝素(PHA)刺激的人外周血淋巴细胞的有丝分裂未见影响,而对分裂周期有延缓作用,对该细胞DNA合成有显著促进作用;然而,上述三种砷化合物达到一定浓度时,对该细胞分裂、细胞周期及细胞DNA合成均有显著抑制作用。砷促进DNA合成的效应有明显的个体差异。不论对细胞DNA合成的促进作用还是抑制作用,三价砷比五价砷的作用更强。
|
| 关 键 词： | 砷 淋巴细胞 DNA合成 |
EFFECTS OF INORGANIC ARSENIC COMPOUNDS ON MITOGENESIS AND DNA SYNTHESIS IN HUMAN BLOOD LYMPHOCYTES |
| |
| Meng Ziqiang Gao Kun Wu Cuiqing.EFFECTS OF INORGANIC ARSENIC COMPOUNDS ON MITOGENESIS AND DNA SYNTHESIS IN HUMAN BLOOD LYMPHOCYTES[J].Journal of Shanxi University (Natural Science Edition),1993,16(4):467-473. |
| |
| Authors: | Meng Ziqiang Gao Kun Wu Cuiqing |
| |
| Abstract: | Effects of arsenic on DNA synthesis in human lymphocytes were biphasic. Either trivalent (arsenic trioxide and sodium arsenite) or pentavalent arsenic compounds (sodium arsenate) at very low concentrations enhanced DNA synthesis in human blood lymphocytes stimulated by phytohamegglutinin (PHA). These arsenic chemicals at certain concentrations decreased the DNA synthesis and reduced the cell mitotic index. There were obvious differences in the individual susceptibility to arsenic-induced DNA synthesis. The effects of stimulating or inhibiting of trivalent arsenic on DNA synthesis were always stronger than that of pentavalent arsenic. |
| |
| Keywords: | Arsenic Lymphocyte DNA synthesis |
| 本文献已被 CNKI 维普 等数据库收录！ |
