| Abstract: | Summary The paper deals with recent advances in chemotherapy of tuberculosis. In view of the fact that chemical analysis has shown the lipoid nature of tubercle bacilli and in view of the favorable therapeutic results obtained by treating leprosy with chaulmoogra-acids, the leading idea of many authors was to synthetize lipoidsoluble substances in order to affect the growth of tubercle bacilli. However, the finding that water-soluble substances as Promin inhibit the growth of the microorganisms showed that the idea to use exclusively fatsoluble substances was not necessarily right. Although the therapeutic effects of Promin are not yet particularly encouraging, the experiments made with this substances are useful as they indicate a new direction for research in chemotherapy of tuberculosis. Some of our own experiments with diaminodiphenylsulphone-derivatives are described. |
