| 小麦高分子量麦谷蛋白亚基1By15N端区同源建模与分子动力学模拟 |
| |
| 引用本文： | 杨曦,黄伟伟,杨广笑,汪越胜,何光源.小麦高分子量麦谷蛋白亚基1By15N端区同源建模与分子动力学模拟[J].河南科技大学学报(自然科学版),2009,30(1). |
| |
| 作者姓名： | 杨曦 黄伟伟 杨广笑 汪越胜 何光源 |
| |
| 作者单位： | 1. 河南科技大学,医学技术与工程学院,河南,洛阳,471003
2. 华中科技大学,中英HUST-RRes基因工程和基因组学联合实验室,湖北,武汉,430074 |
| |
| 基金项目： | 国家重点基础研究发展规划(973计划)，国家自然科学基金 |
| |
| 摘 要： | 通过二级结构预测、折叠识别、同源建模和分子动力学模拟的方法,获得三个小麦高分子量麦谷蛋白亚基1By15 N端区的三维结构模型.模型分析发现,y 型高分子量麦谷蛋白亚基N端的5个半胱氨酸具有两种成键模式,一种是Cys22和Cys44之间形成一个链内二硫键,N端剩余的三个半胱氨酸Cys10,45和55都是自由半胱氨酸用于形成链间二硫键;另一种是Cys22和Cys44,Cys10和Cys55之间形成两对链内二硫键,剩余一个Cys45作为自由半胱氨酸用于形成链间二硫键.
|
| 关 键 词： | 小麦 麦谷蛋白 同源建模 分子动力学模拟 二硫键 |
Homology Modeling and Molecular Dynamics Simulations of N-terminal Domain of Wheat High Molecular Weight Glutenin Subunit 1By15 |
| |
| YANG Xi,HUANG Wei-Wei,YANG Guang-Xiao,WANG Yue-Sheng,HE Guang-Yuan.Homology Modeling and Molecular Dynamics Simulations of N-terminal Domain of Wheat High Molecular Weight Glutenin Subunit 1By15[J].Journal of Henan University of Science & Technology:Natural Science,2009,30(1). |
| |
| Authors: | YANG Xi HUANG Wei-Wei YANG Guang-Xiao WANG Yue-Sheng HE Guang-Yuan |
| |
| Institution: | 1.Medical Technology & Engineering College;Henan University of Science & Technology;Luoyang 471003;China;2.China-UK HUST-RRes Genetic Engineering & Genomics Joint Laboratory;Huazhong University of Science & Technology;Wuhan 430074;China |
| |
| Abstract: | With the application of secondary structure prediction,fold-recognition,3D structure modeling and molecular dynamics simulation,three models for the N-terminal domain of HMW-GS 1By15 were built.Analysis of these models revealed two possible ways of disulfide bridges of the five cysteine residues in N-terminal domain of y-type HMW-GS.One way is that Cys22 and Cys44 form an intramolecular disulfide bridge,and the remaining three cysteine residues of N-terminal domain,Cys10,Cys45 and Cys55,act as free residues... |
| |
| Keywords: | Wheat Glutenin Homology modeling Molecular dynamics simulation Disulfide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
