| 内质网应激反应与衰老相关疾病 |
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| 引用本文： | 常乐,丛羽生. 内质网应激反应与衰老相关疾病[J]. 北京师范大学学报(自然科学版), 2010, 46(4) |
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| 作者姓名： | 常乐 丛羽生 |
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| 作者单位： | 北京师范大学生命科学学院,细胞增殖及调控生物学教育部重点实验室,100875,北京;北京师范大学生命科学学院,细胞增殖及调控生物学教育部重点实验室,100875,北京 |
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| 摘 要： | 内质网是真核细胞合成膜蛋白和分泌蛋白的主要场所,当细胞经历缺氧、钙离子稳态失衡、糖基化异常或内质网内蛋白合成急剧增加时,就会造成腔内未折叠蛋白聚集体的形成,引发细胞毒性.这时便会激活一系列信号通路,通过增加内质网中分子伴侣的数量、降低蛋白合成速率、加快未折叠蛋白降解来保护细胞,当刺激严重或时间过长则会引起细胞凋亡.这种反应就称为内质网应激反应,也叫未折叠蛋白反应.正常人体细胞随着分裂次数增加或受外界因素诱导逐渐进入一种不可逆的细胞周期阻滞,即细胞衰老.细胞衰老会伴随着各种生理生化的变化,如内质网的结果和功能的改变.内质网应激反应会随着细胞衰老而发生一些改变,与衰老相关疾病密切相关而备受关注.因此深入研究内质网应激反应对于揭示衰老及衰老相关疾病的分子机制具有重要的科学意义.
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| 关 键 词： | 内质网应激反应 细胞衰老 老年疾病 |
ENDOPLASMIC RETICULUM RESPONSE AND AGING RELATED DISEASES |
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| CHANG Le,CONG Yusheng. ENDOPLASMIC RETICULUM RESPONSE AND AGING RELATED DISEASES[J]. Journal of Beijing Normal University(Natural Science), 2010, 46(4) |
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| Authors: | CHANG Le CONG Yusheng |
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| Affiliation: | CHANG Le CONG Yusheng(College of Life Sciences,Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education,Beijing Normal University,100875,Beijing,China) |
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| Abstract: | Endoplasmic reticulum(ER) is an organelle where secretory or membrane proteins are synthesized.When cells experience stresses such as hypoxia,unbalanced Ca2+ concentration,abnormal glycosylation or excess protein synthesis,unfolded proteins are accumulated and aggregated in the lumen of the endoplasmic reticulum(ER),this latter process is toxic to cells and can induces serial changes including increased chaperone protein expression,reduced protein synthesis and ER-associated degradation.This coordinated ada... |
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| Keywords: | ER stress response cellular senescence aging relative disease |
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