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Susceptibility variants for male-pattern baldness on chromosome 20p11 |
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| Authors: | Hillmer Axel M Brockschmidt Felix F Hanneken Sandra Eigelshoven Sibylle Steffens Michael Flaquer Antonia Herms Stefan Becker Tim Kortüm Anne-Katrin Nyholt Dale R Zhao Zhen Zhen Montgomery Grant W Martin Nicholas G Mühleisen Thomas W Alblas Margrieta A Moebus Susanne Jöckel Karl-Heinz Bröcker-Preuss Martina Erbel Raimund Reinartz Roman Betz Regina C Cichon Sven Propping Peter Baur Max P Wienker Thomas F Kruse Roland Nöthen Markus M |
| Affiliation: | Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany. axel.hillmer@uni-bonn.de |
| Abstract: | We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway. |
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