Novel regulation and function of Src tyrosine kinase |
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Authors: | Y-C Ma X-Y Huang |
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Institution: | (1) Department of Physiology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021 (USA), Fax: + 1 212 746 8690, e-mail: xyhuang@med.cornell.edu, US |
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Abstract: | Src tyrosine kinase is a critical signal transducer that modulates a wide variety of cellular functions. Misregulation of
Src leads to cell transformation and cancer. Heterotrimeric guanine-nucleotide-binding proteins (G proteins) are another group
of signaling molecules that transduce signals from cell-surface receptors to generate physiological responses. Recently, it
was discovered that Gαs and Gαi could directly stimulate Src family tyrosine kinase activity. This novel regulation of Src
tyrosine kinase by G proteins provides insights into the adenylyl cyclase-independent signaling mechanisms involved in ligand-induced
receptor desensitization, internalization and other physiological processes.
Received 17 August 2001; received after revision 22 October 2001; accepted 24 October 2001 |
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Keywords: | , Src tyrosine kinase, G protein, adenylyl cyclase, receptor desensitization, receptor internalization, |
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