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Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment |
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| Authors: | L Annunziato D Cocchi G di Renzo G L Rossi S Amoroso M Taglialatela E E Müller |
| Institution: | (1) Department of Pharmacology, 2nd School of Medicine at Naples, Via Vanvitelli 32, I-20129 Milan, (Italy);(2) Department of Pharmacology, University of Milan, Via Vanvitelli 32, I-20129 Milan, (Italy);(3) Institute of Animal Pathology, University of Bern, CH-3000 Bern, (Switzerland) |
| Abstract: | Summary Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50  M) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls. |
| Keywords: | Tuberoinfundibular dopaminergic system prolactin estrogen-treated rats prolactin secreting adenoma |
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