| 硫薰山药对大鼠肝肾代谢功能的影响 |
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| 引用本文： | 郭婕,周景洋,颜燕,赵海霞,程东,姚文环. 硫薰山药对大鼠肝肾代谢功能的影响[J]. 实验动物科学, 2010, 27(2): 13-16 |
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| 作者姓名： | 郭婕 周景洋 颜燕 赵海霞 程东 姚文环 |
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| 作者单位： | 1. 山东省疾病控制中心,济南,250014
2. 山东中医药大学附属医院,济南,250011 |
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| 基金项目： | 山东省中医药科技发展计划项目 |
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| 摘 要： | 目的观察硫磺熏蒸山药对雌、雄大鼠肝肾脂质过氧化水平和抗氧化能力的变化。方法将实验动物随机分为4组,其中3组分别给予山药饮片、市售熏蒸山药饮片、饱和熏蒸山药饮片水提浓缩液(5 g/mL),掺入基础饲料50 g/kg;正常对照组给予基础饲料。测定14 w后大鼠肝肾中丙二醛(MDA)含量、GSH-Px活力和SOD活力。结果(1)山药有一定抗氧化作用;(2)不同浓度硫磺薰蒸山药对不同脏器引起的氧化应激作用不同(与浓度有关),并且有器官差异性;⑶高浓度硫磺薰蒸山药对雌雄大鼠造成的氧化损伤作用,在不同脏器间存在性别差异。结论长期食用经高浓度硫磺熏蒸的山药有可能引起肝肾氧化损伤。
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| 关 键 词： | 山药 硫磺熏蒸 肝脏 肾脏 脂质过氧化作用 |
| 收稿时间： | 2010-04-28 |
Effect of Sulfur Fumigated Dioscorea opposita Thunb on Oxidative Stress in Liver and Kidney of Rats |
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| GUO Jie,ZHOU Jing-yang,YAN Yan,ZHAO Hai-xia,CHENG Dong,YAO Wen-huan. Effect of Sulfur Fumigated Dioscorea opposita Thunb on Oxidative Stress in Liver and Kidney of Rats[J]. Laboratory Animal Science, 2010, 27(2): 13-16 |
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| Authors: | GUO Jie ZHOU Jing-yang YAN Yan ZHAO Hai-xia CHENG Dong YAO Wen-huan |
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| Affiliation: | GUO Jie1,ZHOU Jing-yang1,YAN Yan1,ZHAO Hai-xia2,CHENG Dong1,YAO Wen-huan1(1.Sh,ong Center for Disease Control , Prevention,Jinan 250014,China)(2.Affiliated Hospital of Sh,ong University of Chinese Medicine,Jinan 250011,China) |
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| Abstract: | Objective To investigate the influence of sulfur fumigated Dioscorea opposita Thunb on peroxidation and antioxidation in liver and kidney of rats.Methods Wistar rats were divided randomly into 4 groups,one control and three experimental groups administrated diets mixed with concentrated extractions from unfumigated,commercial and sulfur fumigated Dioscorea opposita Thunb respectively.The level of MDA and activities of SOD and GSH-Px 14 weeks after treatment were measured.Results(1) Dioscorea opposita Thunb ... |
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| Keywords: | Dioscorea opposita Thunb Sulphur fumigation Liver Kidney Lipid peroxidation |
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