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| EC,ASMC and Macrophage Oxidize Human Low Density Lipoprotein | |
| 引用本文： | Dai Zhao|ming,Wu Jun|zhu,Li Xiao| ming,Chen Li|da,Hong Jia|ling Department of Biochemistry,Medical College,Wuhan University,Wuhan 430071,Hubei,China. EC,ASMC and Macrophage Oxidize Human Low Density Lipoprotein[J]. 武汉大学学报:自然科学英文版, 2003, 8(1): 130-134. DOI: 10.1007/BF02902081 |
| 作者姓名： | Dai Zhao|ming Wu Jun|zhu Li Xiao| ming Chen Li|da Hong Jia|ling Department of Biochemistry Medical College Wuhan University Wuhan 430071 Hubei China |
| 作者单位： | Dai Zhao|ming，Wu Jun|zhu，Li Xiao| ming，Chen Li|da，Hong Jia|ling Department of Biochemistry，Medical College，Wuhan University，Wuhan 430071，Hubei，China |
| 基金项目： | SupportedbyFoundationforYoungDoctorofWuhanUniversity (30 1 2 70 0 61 ) |
| 摘 要： | Ｉｔｉｓｋｎｏｗｎｔｈａｔｄｕｒｉｎｇａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ (Ａｓ)ｏｘｉｄｉｚｅｄｌｏｗｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎ (ｏｘ ＬＤＬ)ｐｌａｙｓａｎｉｍｐｏｒｔａｎｔｒｏｌｅｔｈａｔｉｓｔａｋｅｎｕｐｂｙａｒｔｅｒｉａｌｗａｌｌｍａｃｒｏｐｈａｇｅｓａｔａｎｅｎｈａｎｃｅｄｒａｔｅ ,ｌｅａｄｉｎｇｔｏｃｅｌｌｕｌａｒｃｈｏｌｅｓｔｅｒｏｌａｃｃｕｍｕｌａｔｉｏｎａｎｄｆｏａｍｃｅｌｌｆｏｒｍａｔｉｏｎ .ＴｈｅａｔｈｅｒｏｇｅｎｉｃｉｔｙｏｆｏｘｉｄｉｚｅｄＬＤＬａｌｓｏｉｎｖｏｌｖ… |
EC,ASMC and macrophage oxidize human low density lipoprotein |
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| Dai Zhao-ming,Wu Jun-zhu,Li Xiao-ming,Chen Li-da,Hong Jia-ling. EC,ASMC and macrophage oxidize human low density lipoprotein[J]. Wuhan University Journal of Natural Sciences, 2003, 8(1): 130-134. DOI: 10.1007/BF02902081 | |
| Authors: | Dai Zhao-ming Wu Jun-zhu Li Xiao-ming Chen Li-da Hong Jia-ling |
| Affiliation: | (1) Department of Biochemistry, Medical College, Wuhan University, 430071 Wuhan, Hubei, China |
| Abstract: | To investigate the mechanism of LDL oxidation i n vivo , LDL was incubated with endothelium cell (EC),artery smooth muscle cel l (ASMC) and macrophage, and then the change of myeloperoxidase (MPO) activity i n cell and medium and the oxidation of LDL by those three cells were assessed. T he result showed that LDL promoted the activity of cellular and secretive myelop eroxidase which was concentration|dependent on LDL; with elevation of MPO activ ity, oxidation of LDL intensified, which was expressed by the formation of conju gated dienes and the elevation of thiobarbituric acid teactive substance (TBARS ). Macrophage's MPO activity went up with the increase of LDL at both low and h igh concentration; EC's MPO activity went up with the increase of LDL only at h igh concentration and ASMC's MPO activity wasn't sensitive to LDL concentratio n change. The results suggest that Macrophage might be crucial to the oxidation of LDL in vivo , in which MPO might play an important role. |
| Keywords: | low density lipoprotein oxidation in vivo myeloperoxidase |
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