乳腺癌组织中C-erbB-2、p53、ER、PR的表达与预后因素的关系

目的：探讨乳腺癌组织中雌激素受体（ER）、孕激素受体（PR）、c-erbB-2、p53癌基因表达及其与淋巴结转移、临床分期的关系．方法：采用免疫组织化学技术S-P法检测80例乳腺癌组织中c-erbB-2、p53、ER、PR的表达．结果：c-erbB-2、p53、ER、PR的阳性率分别为：48．75％（39／80）、56．25％（45／80）、52．5％（42／80）、58．75％（47／80）；c-erbB-2、p53在ER、PR均阳性组的表达低于二者均阴性组的表达（P〈0．05）；c-erbB-2、p53在淋巴结转移组中表达高于淋巴结未转移组的表达（P〈0．05）；ER与PR的表达呈显著相关性，与临床分期及组织学类型无关．结论：c-erbB-2、p53、ER、PR与乳腺癌的发生发展有关，是指导内分泌治疗的重要指标，有利于客观评估乳腺癌的生物学行为，判定预后．

Correlation between Expression of c-erbB-2,p53,ER and PR in Breast Cancer and Patient's Prognosis

Objective： To explore the correlation between the metastasis of axillary lymph nodes and clinical stages and the expression of c- erbB-2, p53, ER and PR in breast cancer. Methods ： The expression of c-erbB-2, p53, ER and PR was detected by immunohisto chemical technique in 80 cases of breast cancer. Results： ①The positive rate of expression of c-erbB-2, p53, ER , PR was 48.75 % （39/80）, 56.25 % （45/80）, 52.5 % （42/80） and 58.75 % （47/80） respectively. ② The positive rate of expression of c-erbB-2, p53 in the positive group with the expression of ER, PR was lower than that in the negative group（p〈0.05）. The positive rates of expression of c-erbB -2, p53 in the group with the lymph node metastasis was higher than that in non - lymph node metastasis group（p〈0.05）, ③ER expression had a positive correlation with PR expression. No significant association of expression of ER, PR with clinical stages and histological types was noted. Conclusion： c-erbB-2, p53, ER, PR and the occurrence and development of breast cancer are interrelated. It is an important index to guide endocrine treatment. It is helpful for objectively estimating biological behavior of breast cancer and judging the patient＇s prognosis.