Use of the specific benzodiazepine antagonist,Ro 15-1788, in studies of physiological dependence on benzodiazepines |
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| Authors: | R. Cumin E. P. Bonetti R. Scherschlicht W. E. Haefely |
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| Affiliation: | (1) Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. Ltd, CH-4002 Basel, (Switzerland) |
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| Abstract: | ![]()
Summary The specific benzodiazepine antagonist, Ro 15-1788, elicited withdrawal symptoms in squirrel monkeys, cats, rats and mice made tolerant and physically dependent by subchronic administration of high doses of diazepam, lorazepam or triazolam. |
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