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P16及COX-2蛋白在宫颈癌中表达及意义
引用本文:张红梅,吴华真,郭景玲. P16及COX-2蛋白在宫颈癌中表达及意义[J]. 世界科技研究与发展, 2012, 34(5): 842-843,847
作者姓名:张红梅  吴华真  郭景玲
作者单位:山东省济宁市第一人民医院,济宁,272111
摘    要:目的 探讨P16及COX-2蛋白在宫颈癌中表达及意义.方法 收集宫颈活检或手术标本138例,采用免疫组织化学方法分别检测P16及COX-2蛋白的表达,并分析结果.结果 正常宫颈组织、宫颈低级别上皮内瘤变(LSIL)、宫颈高级别上皮内瘤变(HSIL)、宫颈癌中P16蛋白阳性表达分别为0%(0/30)、42.3% (11/26)、71.9%(23/32)、92%(46/50).COX-2蛋白阳性表达分别为3.3%(1/30)、50%(13/26)、75%(24/32)、88% (44/50).随着宫颈病变分级升高,P16及COX-2蛋白阳性率逐渐上升,统计学差异有显著性(p<0.05);结论 P16及COX-2的高表达在宫颈癌的发生、发展中均起作用.

关 键 词:宫颈癌  P16蛋白  COX-2蛋白

Expression of P16 Protein and COX-2 Protein in Cervical Cancer
ZHANG Hongmei , WU Huazhen , GUO Jingling. Expression of P16 Protein and COX-2 Protein in Cervical Cancer[J]. World Sci-tech R & D, 2012, 34(5): 842-843,847
Authors:ZHANG Hongmei    WU Huazhen    GUO Jingling
Affiliation:( Shangdong Jining First People's Hospital, Jining 272111 )
Abstract:Objective To explore expression of PI6 protein and COX-2 protein in cervical cancer. Methods 138 eases o f submission of cervi- cal biopsy or surgical specimens were collected.. The expression of P16 protein and COX-2 protein were detected and analysed by imm-Uno- bistoehemistry. Results Positive 'expression rates of p16 were 0% (0/30) ,42. 3% (11/26) ,71.9% (23/32) ,92% (46/50) ,and 3.3% ( 1/ 30 ) ,50% (13/26) ,75 % ( 24/32 ) , 88 % ( 44/50 ) for COX-2 respectively o With the increase of tumor differentiation, positive expression rate of P16 and COX-2 were increased gradually (p 〈0.05 ). Conclusion The P16 protein or COX-2 protein may play an important role iv. cervical cancer development and progression.
Keywords:cervical carcinoma  P16 protein  COX-2 protein
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