Granulocytosis induced in vivo by a mouse marrow stromal cell line, BMA1, which produces colony stimulating factor |
| |
Authors: | K Fujita Y Shimomura J Fujita K J Mori |
| |
Abstract: | Nude mice were inoculated with BMA1 cells. These are cells which produce granulocyte-macrophage colony stimulating factor (GM-CSF); They are derived from mouse bone marrow stromal cells transfected with adenovirus 5 DNA. Progressive neutrophilia developed as the tumor grew, but disappeared quickly after local tumor excision. Media conditioned with tumor cells had GM-CSF but neither erythropoietin nor burst-promoting activity. In all the tumors which developed, focal areas of bone formation were found among fibrosarcomatous tissues. |
| |
Keywords: | |
|
|