| 知母皂苷的体内外代谢研究进展 |
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| 引用本文： | 郭晶,薛睿,江蔚新. 知母皂苷的体内外代谢研究进展[J]. 北京联合大学学报(自然科学版), 2014, 28(2): 13-17 |
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| 作者姓名： | 郭晶 薛睿 江蔚新 |
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| 作者单位： | 哈尔滨商业大学药学院,哈尔滨 150076;中国科学院上海药物研究所,上海201203;中国科学院上海药物研究所,上海,201203;哈尔滨商业大学药学院,哈尔滨,150076 |
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| 基金项目： | 国家科技重大专项重大新药创制（2012ZX09301001-001）. |
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| 摘 要： | 知母皂苷是一系列来源于中药知母的、具有多种药理活性的甾体皂苷类天然产物。通过对近年来国内外关于知母皂苷体体内外研究的文献进行综述,有利于深入探索该类成分体内药效的物质基础和作用机制,为进一步研究知母皂苷的药理作用提供化学物质依据,为新药研发提供一定的理论依据。
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| 关 键 词： | 知母 知母皂苷 代谢 进展 |
Research Progress on Metabolism of Timosaponins in vivo and in vitro |
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| GUO Jing,XUE Rui,JIANG Wei-xin. Research Progress on Metabolism of Timosaponins in vivo and in vitro[J]. Journal of Beijing Union University, 2014, 28(2): 13-17 |
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| Authors: | GUO Jing XUE Rui JIANG Wei-xin |
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| Affiliation: | 1. Harbin University of Commerce, Harbin 150076, China; 2. Shanghai Institute of Materia Mediea, Chinese Academy of Sciences, Shanghai 201203, China) |
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| Abstract: | Timosaponins, a series of steroid saponins isolated from Anemarrhena asphodeloides were confirmed to possess many pharmacological activities. In this paper, the metabolism studies of timosaponins in vitro and in vivo were reviewed, which would be a foundation for the further exploration of the effective material basic and mechanism of these compounds. It could provide not only chemical basis for the further study of the pharmacological effects of timosaponins but also some theoretical basis for new drug development and application. |
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| Keywords: | Anemarrhena asphodeloides Timosaponin Metabolism Progress |
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