Expression and functional importance of innate immune receptors by intestinal epithelial cells |
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Authors: | Rute?Marques Email author" target="_blank">Ivo?G?BonecaEmail author |
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Institution: | (1) Development of Lymphoid Tissue Unit, Institut Pasteur, 25-28 rue du Dr. Roux, Paris, 75724, France;(2) Group Biology and Genetics of the Bacterial Cell Wall, Institut Pasteur, 25-28 rue du Dr. Roux, Paris, 75724, France;(3) INSERM, Group Avenir, Paris, 75015, France |
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Abstract: | Pattern recognition receptors are somatically encoded and participate in the innate immune responses of a host to microbes.
It is increasingly acknowledged that these receptors play a central role both in beneficial and pathogenic interactions with
microbes. In particular, these receptors participate actively in shaping the gut environment to establish a fruitful life-long
relationship between a host and its microbiota. Commensal bacteria engage Toll-like receptors (TLRs) and nucleotide oligomerization
domain (NOD)-like receptors (NLRs) to induce specific responses by intestinal epithelial cells such as production of antimicrobial
products or of a functional mucus layer. Furthermore, a complex crosstalk between intestinal epithelial cells and the immune
system is initiated leading to a mature gut-associated lymphoid tissue to secrete IgA. Impairment in NLR and TLR functionality
in epithelial cells is strongly associated with chronic inflammatory diseases such as Crohn’s disease, cancer, and with control
of the commensal microbiota creating a more favorable environment for the emergence of new infections. |
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Keywords: | |
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