A dynamic view of peptides and proteins in membranes |
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Authors: | B Bechinger |
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Institution: | (1) Institut de chimie, CNRS, Université Louis Pasteur, UMR 7177, 4 rue Blaise Pascal, 67000 Strasbourg, France |
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Abstract: | Biological membranes are highly dynamic supramolecular arrangements of lipids and proteins, which fulfill key cellular functions.
Relatively few high-resolution membrane protein structures are known to date, although during recent years the structural
databases have expanded at an accelerated pace. In some instances the structures of reaction intermediates provide a stroboscopic
view on the conformational changes involved in protein function. Other biophysical approaches add dynamic aspects and allow
one to investigate the interactions with the lipid bilayers. Membrane-active peptides fulfill many important functions in
nature as they act as antimicrobials, channels, transporters or hormones, and their studies have much increased our understanding
of polypeptide-membrane interactions. Interestingly several proteins have been identified that interact with the membrane
as loose arrays of domains. Such conformations easily escape classical high-resolution structural analysis and the lessons
learned from peptides may therefore be instructive for our understanding of the functioning of such membrane proteins.
Received 11 March 2008; received after revision 2 May 2008; accepted 5 May 2008 |
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Keywords: | " target="_blank"> Protein-lipid interactions GPCR channel pore Bcl-2 colicin alamethicin melittin |
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