The metabolism of the male antifertility agent 1-amino-3-chloropropan-2-ol in the rat |
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| Authors: | A. R. Jones Carole Murcott D. H. Milton Jennifer Flynn |
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| Affiliation: | (1) Biochemistry Department, University of Sydney, 2006 Sydney, N. S. W., Australia;(2) Present address: Pharmacology Department, Manchester University, M13 9PL Manchester, England |
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| Abstract: | Summary The male antifertility agent 1-amino-3-chloropropan-2-ol (ACP,I) has been shown to be metabolized to -chlorohydrin (III) and metabolites of-chlorohydrin. This accounts for the similar antifertility and renal toxicity effects of both compounds. |
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