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Influence of alpha-MSH and ACTH on cortical bone remodelling in hypophysectomized rats. |
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| Authors: | A Stenstr?m L I Hansson K G Thorngren |
| Abstract: | Hypophysectomy increases both periosteal resorption and endosteal apposition along the femur diaphysis in rat. Administration of alpha-MSH decreased the periosteal resorption but had no effect on the endosteal apposition. ACTH had only minor effects on the endosteum. Thus, alpha-MSH and ACTH, in the doses used, have different effects on cortical bone in rat. The effect of alpha-MSH on cortical bone could be an effect of the hormone alone or by its stimulation of other factors. |
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