| 嗜铬细胞分泌的模型研究 |
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| 引用本文： | 韦顺会,瞿安连,吴鸿修,周专.嗜铬细胞分泌的模型研究[J].华中科技大学学报(自然科学版),1998(10). |
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| 作者姓名： | 韦顺会 瞿安连 吴鸿修 周专 |
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| 作者单位： | 华中理工大学生物物理和生物化学研究所 |
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| 基金项目： | 国家杰出青年基金（39525009），国家自然科学基金资助项目（69571014，69671007） |
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| 摘 要： | 在大鼠肾上腺嗜铬细胞上应用全细胞膜片钳和膜电容检测技术，对细胞分泌的模型进行了研究．对Ｈｅｉｎｅｍａｎｎ等提出的准备释放库Ｂ，进行了更为精确深入的分析，提出了新的论据和修改内容．证实在距细胞膜 Ｃａ２＋通道３０ｎｍ处存在立即释放库，在距Ｃａ２＋通道３００ｎｍ处存在可释放库．通过内分泌细胞分泌模型分析了Ｃａ２＋的控制作用以及囊泡释放过程的时序特征．
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| 关 键 词： | 分泌 动力学 模型 |
A Kinetic Model of Control on Secretion in Chromaffin Cells |
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| Wei Shunhui,Doctoral Candidate.A Kinetic Model of Control on Secretion in Chromaffin Cells[J].JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY.NATURE SCIENCE,1998(10). |
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| Authors: | Wei Shunhui Doctoral Candidate |
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| Institution: | Wei Shunhui,Doctoral Candidate, Institute of Biophysics and Biochemistry,HUST,Wuhan 430074,China. Qu Anlian,Wu Hongxiu,Zhou Zhuan |
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| Abstract: | Using whole-cell patch clamp and membrane capacitance measurement technique, a secre- tary model of chromaffin cells in rat adrenal is studied. The releasable vesicles pool propounded by Heinemann is analyzed with more precision, the revision and the new evidence given. It is confirm that immediately releasable pool (IRP) and readily releasable pool (RRP) are respectively distributed with- in about 30nm and 300nm from Ca2+ channels. A corresponding model secretary in endocrine cell can simulate the dynamics of vesicles pools with the control of Ca2+. |
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| Keywords: | secretion kinetic model |
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