Chemotaxis is not a special case of haptotaxis |
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| Authors: | H U Keller J H Wissler J Ploem |
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| Institution: | (1) Department of Pathology, University of Bern, Freiburgstrasse 30, CH-3010 Bern, (Switzerland);(2) Arbeitsgruppe Biochemie, Abteilung für experimentelle Kardiologe, Max-Planck-Institut für physiologische und klinische Forschung, D-6350 Bad Nauheim, (Federal Republic of Germany);(3) Department of Cytochemistry, Leiden University Medical Center, Leiden, (The Netherlands) |
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| Abstract: | Summary Serum peptides containing classical anaphylatoxin (CAT) produce marked chemotactic orientation of human neutrophil granulocytes without modifying cell attachment to the substratum. Furthermore gradients of adhesion produced with gammaglobulins fail to induce morphological orientation of neutrophils. The results suggest that chemotaxis is not a special case of haptotaxis.The excellent technical assistance of Miss M. Schuster, Mrs A. Damschen and Mr M. Arnold is gratefully acknowledged. This work was supported by the Swiss National Science Foundation and the  Sandoz-Stiftung zur Förderung der Medizinisch-Biologischen Forschung. |
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