| 呋喃[3,2-b]吲哚类化合物碱性条件下扩环重排反应 |
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| 引用本文： | 张志国,曹夕阳,王港,方世亮,吴昊,张贵生.呋喃[3,2-b]吲哚类化合物碱性条件下扩环重排反应[J].河南师范大学学报(自然科学版),2022,50(2):95-101. |
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| 作者姓名： | 张志国 曹夕阳 王港 方世亮 吴昊 张贵生 |
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| 作者单位： | 河南师范大学化学化工学院,河南新乡453007 |
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| 摘 要： | 吲哚类化合物的重排扩环反应通常是在酸性条件下完成.研究发展了一种吲哚类化合物在碱性条件下的扩环重排反应.通过在1 ∶ 1(体积比)的乙二醇和水的混合溶剂中回流呋喃3,2-b]吲哚类化合物和氢氧化钾的混合物可以将呋喃3,2-b]吲哚类化合物高产率地转化成喹啉酮类化合物.
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| 关 键 词： | 呋喃[3 2-b]吲哚 2-喹啉酮 扩环反应 吲哚重排 碱性条件重排 |
Ring expansion and rearrangement of furo[3,2-b]indoles under basic conditions |
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| Zhang Zhiguo,Cao Xiyang,Wang Gang,Fang Shiliang,Wu Hao,Zhang Guisheng.Ring expansion and rearrangement of furo[3,2-b]indoles under basic conditions[J].Journal of Henan Normal University(Natural Science),2022,50(2):95-101. |
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| Authors: | Zhang Zhiguo Cao Xiyang Wang Gang Fang Shiliang Wu Hao Zhang Guisheng |
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| Institution: | ,School of Chemistry and Chemical Engineering, Henan Normal University |
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| Abstract: | The rearrangement and ring expansion reactions of indoles are commonly achieved under acidic conditions. We have realized the ring expansion and rearrangement reaction under alkaline conditions. A range of substituted quinolinones were obtained in moderate to good yields by refluxing the mixture of furo3,2-b]indoles and KOH in a 1:1(volume ratio)mixed solvent of ethylene glycol and water. |
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| Keywords: | furan[3 2-b]indoles 2-quinolinones ring expansion indoles rearrangement rearrangement under basic conditions |
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