4-异丙某萘并[2,3-d]-1,3-二氧五环衍生物的合成

４－异丙基萘并［２，３－ｄ］－１，３－二氧五环衍生物具有与半棉酚类似的碳架结构，可作为合成棉酚类似物的中间体。用２，３－二羟基茶为起始原料合成４－溴萘并［２，３－ｄ］－１，３－二氧五环后在同一反应釜内一步完成锂－溴交换，与丙酮加成及脱水反应而直接分离出４－异丙烯基萘并［２，３－ｄ］－１，３－二氧五环。在把－碳催化剂存在下常压催化加氢后即在萘环上引入异丙基。不同合成路线的比较显示了这一方法的优越性。所合成的这些个异同基萘并［２，３－ｄ］－１，３－二氧五环衍生物均未见文献报导。

Synthesis of 4-Isopropylnaphtho(2, 3-d)-1,3- dioxolane Derivatives

Isopropylnaphtho(2, 3-d)-1, 3-dioxolane derivatives have analogous carbon frame to the semigossypol. Using 2, 3-dihydrooxynaph- thalene as starting material, 4-bromonaphtho (2, 3-d)-l, 3-dioxolane is prepared. By the continuing lithium-bromine exchange, addition with absolute acetone and immediately dehydration in one pot, 4- isopropynylnaphtho(2,3-d)-1,3-dioxolane is obtained. Hydrogenation of the isopropynyl group is proceeded in present of Pd-carbon catalyst. With directly formolnaphtho(2, 3-d)-1, 3-dioxolane is prepared. These 4-isopropylnaphtho (2, 3-d)-l, 3-dioxolane derivatives have not been found in literature.