发酵过程中比生长率的在线估计

提出了一种基于在线可测的二氧化碳释放率的需氧发酵过程中比生长率的在线估计方法,并且采用优化的方法进行模型中重要参数的选择.由于二氧化碳释放率容易检测,所以这种估计方法非常容易实现.在诺西肽发酵过程的应用中,利用所提出的方法得到比生长率,进而计算生物量,得出的估计值与实验值吻合得很好,表明了该估计方法的可靠性与实用性.

On-Line Estimation of Specific Growth Rate in Fermentation Process

The specific growth rate is one of the key parameters in fermentation process,but to get its value on-line is difficult because of lack of reliable sensors. An on-line estimation of the specific growth rate in aerobic fermentation process is thus proposed by measuring CER (carbon dioxide excretion rate) and then selecting the important parameters in the model through optimization. It is very easy to implement since the carbon dioxide excretion rate can be obtained easily. This method has been applied to Nosiheptide fermentation process in which the specific growth rate is given by an estimator computing the biomass. The results show that the estimated values conform well with the measured values,i.e.,the proposed method is reliable and practical.