超声吸收和生物组织的熵产生——一个癌症理疗的新方案

通过热力学计算证明,超声在生物组织中的粘滞耗散和热耗散引起的吸收低于化学弛豫引起的非经典吸收,低频低强度的超声吸收在生物组织中的熵产生对于癌细胞和正常细胞是不同的,这种不同联系于二者的酸度差异.理论计算证明,低频低强度的超声照射可以导致癌细胞和正常细胞熵产生率的倒转,从而可以改变熵流方向,抑止癌的毒性信息流的扩散.这提供了癌症理疗的一个新方案.

Ultrasonic Absorption and Entropy Production in Biological Tissue A Novel Approach to Anticancer Physiotherapy

Entropy production of tumor cells is higher than that of normal cells,therefore entropy current is directed from tumor towards healthy cells.Howev-er,ultrasound absorption results in additional entropy production in tissues.Thedifferences in ultrasonic absorption are related to pH since tumor is more acidicthan normal tissue around the tumor.We demonstrated that the ultrasound ab-sorption will increase the entropy in normal tissue more efficiently than in thetumor.Consequently the direction of entropy flow between two kind of cellsmay be reversed under the irradiation of ultrasound.Entropy flows from healthytissue to cancerous tissue after ultrasonic treatment can contribute to the forma-tion of barrier between the two different tissues,blocking the propagation ofharmful information of cancer into normal tissue.Based on above studies wesuggest that the low intensity(several percents of 1 Watt/cm2) and low fre-quency(1 MHz or lower) ultrasound irradiation may be an efficient tool for thephysiotherapy of solid tumors.