|
|||||
|
|
Derivate des 6,11-Dihydrodibenz(b,e)thiepins,eine neue Gruppe von psychotropen Substanzen |
|
| Authors: | M. Protiva M. Rajšner V. Seidlová E. Adlerová Z. J. Vejdělek |
| Affiliation: | (1) Forschungsinstitut für Pharmazie und Biochemie, Prag, Tschechoslowakei |
| Abstract: | Summary Reactions of phthalide and 6-chlorophthalide with sodium salts of thiophenols gaveo-(phenylmercaptomethyl)benzoic acids (III), which were cyclized by the action of polyphosphoric acid to 6, 11-dihydrodibenz(b,e)-thiepin-11-ones (1). These ketones were treated with 3-di-methylaminopropylmagnesium chloride and other basic Grignard reagents and the products (IV) dehydrated to a series of 11-(aminoalkylidene)-6,11-dihydrodibenz(b,e)-thiepins (V), the hydrochlorides of which show psychotropic activity. 6. Mitt. Synthetische Ataractica, 5. Mitt. siehe  eskoslov. farm.11, im Druck (1962). |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |