Isolation from rat brain of a metabolic product,desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil) |
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| Authors: | J. R. Gillette J. V. Dingell F. Sulser R. Kuntzman B. B. Brodie |
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| Affiliation: | (1) Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland |
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| Abstract: | Zusammenfassung Nach Verabreichung von Imipramin (Tofranil) wurde aus dem Gehirn von Ratten Desmethylimipramin, das N-Monomethylderivat, isoliert. Dieser Metabolit beziehungsweise dessen Anreicherungin vivo scheint für die antidepressive Wirkung von Imipramin verantwortlich zu sein.
Presented in part as an abstract in Fed. Proc.20, 321 (1961). Some of the material in this communication is taken from a dissertation byJ. V. Dingell to be submitted to the Graduate School of Georgetown University in partial fulfillment of the requirements for the degree of Doctor of Philosophy. |
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