Molecular mechanisms in therapy of acid-related diseases |
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| Authors: | J M Shin O Vagin K Munson M Kidd I M Modlin G Sachs |
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| Institution: | (1) Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA;(2) VA Greater Los Angeles Healthcare System, West LA Medical Center, 11301 Wilshire Boulevard, Building 113, Los Angeles, California, 90073, USA;(3) Department of Surgery, Yale University School of Medicine, TMP202, 333 Cedar Street, New Haven Connecticut, 06520-8062, USA |
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| Abstract: | Inhibition of gastric acid secretion is the mainstay of the treatment of gastroesophageal reflux disease and peptic ulceration;
therapies to inhibit acid are among the best-selling drugs worldwide. Highly effective agents targeting the histamine H2 receptor
were first identified in the 1970s. These were followed by the development of irreversible inhibitors of the parietal cell
hydrogen-potassium ATPase (the proton pump inhibitors) that inhibit acid secretion much more effectively. Reviewed here are
the chemistry, biological targets and pharmacology of these drugs, with reference to their current and evolving clinical utilities.
Future directions in the development of acid inhibitory drugs include modifications of current agents and the emergence of
a novel class of agents, the acid pump antagonists.
Received 30 May 2007; received after revision 15 August 2007; accepted 13 September 2007 |
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| Keywords: | Gastric acid secretion peptic ulcer gastroesophageal reflux disease proton pump inhibitors pharmacology H K ATPase |
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