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The finished DNA sequence of human chromosome 12 |
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| Authors: | Scherer Steven E Muzny Donna M Buhay Christian J Chen Rui Cree Andrew Ding Yan Dugan-Rocha Shannon Gill Rachel Gunaratne Preethi Harris R Alan Hawes Alicia C Hernandez Judith Hodgson Anne V Hume Jennifer Jackson Andrew Khan Ziad Mohid Kovar-Smith Christie Lewis Lora R Lozado Ryan J Metzker Michael L Milosavljevic Aleksandar Miner George R Montgomery Kate T Morgan Margaret B Nazareth Lynne V Scott Graham Sodergren Erica Song Xing-Zhi Steffen David Lovering Ruth C Wheeler David A Worley Kim C Yuan Yi Zhang Zhengdong Adams Charles Q Ansari-Lari M Ali Ayele Mulu Brown Mary J Chen Guan |
| Institution: | Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. sscherer@bcm.tmc.edu |
| Abstract: | Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing approximately 4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents. |
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