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| 顺铂水溶液降解产物-羟桥双核铂(Ⅱ)化合物的制备和结构 | |
| 引用本文： | 谌喜珠,谢明进,叶青松,刘伟平,余尧,常桥稳,侯树谦.顺铂水溶液降解产物-羟桥双核铂(Ⅱ)化合物的制备和结构[J].云南大学学报(自然科学版),2009,31(4):389-392. |
| 作者姓名： | 谌喜珠 谢明进 叶青松 刘伟平 余尧 常桥稳 侯树谦 |
| 作者单位： | 1. 昆明贵金属研究所化学与药物研究室, 云南昆明 650106; 2. 云南大学化学科学与工程学院, 云南昆明 650091 |
| 摘 要： | 制备抗癌药顺铂和卡铂在水溶液中的降解产物-羟桥双核铂(Ⅱ)化合物,研究其化学结构.以顺铂为起始原料,通过水合和313nm紫外光照射,分离出目标化合物.通过测定铂含量,ESI-MS,1H NMR和单晶X衍射分析测定其结构.所得到的化合物为以羟基搭桥的双核铂(Ⅱ)配合物,中心离子与2个氮原子和2个氧原子组成平面正方形,2个中心离子之间的距离为0.3095nm,有弱作用.2个配位平面的二面角为2.7°,几乎处于同一平面.2个硝酸根处于配位的外界. |
| 关 键 词： | 顺铂 水溶液 降解产物 合成 结构 |
| 收稿时间： | 2009-1-6 |
Preparation and characterization of the hydroxy-bridged dimeric-platinum compound |
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| CHEN Xi-Zhu,XIE Ming-Jin,YE Qing-song,LIU Wei-Ping,YU Yao,CHANG Qiao-wen,HOU Shu-qian.Preparation and characterization of the hydroxy-bridged dimeric-platinum compound[J].Journal of Yunnan University(Natural Sciences),2009,31(4):389-392. | |
| Authors: | CHEN Xi-Zhu XIE Ming-Jin YE Qing-song LIU Wei-Ping YU Yao CHANG Qiao-wen HOU Shu-qian |
| Institution: | 1. Chemistry and Pharmacy Laboratory, Kunming Institute of Precious Metals, Kunming 650106, China; 2. School of Chemistry, Yunnan University, Kunming 650031, China |
| Abstract: | To prepare and characterize the hydroxyl-bridged dimeric platinum compound,a degradation product of cisplatin in aqueous solution.The compound was prepared via aquation of cisplatin,followed by irradiation at 313 nm.The chemical structures were characterized by elemental analysis,ESI-MS,1H NMR,along with X-ray crystal structure.The compound was determined to be a dimeric platinum(Ⅱ) complex with two hydroxyl groups as its bridged ligand.There are two expected Pt(Ⅱ) square planes.The angle formed between the planes is 2.7°,suggesting the two planes are actually in the same plane.The length of Pt-Pt is 3.095 and two nitrate ions lies outside the coordinated sphere. |
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