高原地区慢阻肺急性加重期合并慢性肺心病抗氧化治疗疗效分析

目的探讨高原地区慢性阻塞性肺疾病急性加重期合并慢性肺心病抗氧化治疗的临床效果.方法高原地区慢性阻塞性肺疾病急性加重期合并慢性肺心病患者118例,所有入组患者随机分为2组,根据不同治疗方案分为:常规治疗加用氨溴索患者59例为对照组,常规治疗加用红景天患者59例为观察组,疗程4周,比较两组患者的肺功能指标、动脉血气指标、血清学指标改变情况及治疗效果.结果治疗后,两组患者FEV1,FEV1/FVC,PaO2,SOD,GSH,T-AOC均显著升高,两组患者PaCO2,8-isoPGF2α,MDA显著降低;观察组患者FEV1,FEV1/FVC,PaO2,SOD,GSH,T-AOC,治疗总有效率均明显高于对照组;观察组患者PaCO2,8-isoPGF2α,MDA明显低于对照组,差异均具有统计学意义(P0.05).结论红景天与氨溴索均是治疗高原地区慢性阻塞性肺疾病急性加重期合并慢性肺心病的有效药物,红景天的治疗效果更佳,可明显改善患者的肺功能、动脉血气及血清学指标.

Curative Effect of Antioxidant Treatment on Chronic Pulmonary Heart Disease Complicated in the Acute Exacerbation Period of Chronic Obstructive Pulmonary Diseases in Plateau Area

Objective To investigate the clinical effect of antioxidant treatment on chronic pulmonary heart disease complicated in the acute exacerbation period of chronic obstructive pulmonary disease in plateau area. Method 118 patients in the acute exacerbation of chronic obstructive pulmonary diseases complicated with chronic pulmonary heart disease in plateau area were divided into two groups. 59 patients treated with the routine therapy plus ambroxol were control group. 59 patients treated with the routine therapy plus rhodiola were observation group. The course of treatment was 4 weeks. Changes in pulmonary function indexes, arterial blood gas indexes, serum indexes and therapeutic effect were compared between two groups. Results After the treatment, FEV1 ,FEV1/FVC, PaO2, SOD, GSH and T-AOC significantly increased while PaCO2,8-isoPGF2α and MDA significantly decreased in two groups. FEV1, FEV1/FVC, PaO2, SOD, GSH, T-AOC and the total effective rate in the observation group were significantly higher than those in the control group. PaCO2,8-isoPGF2α and MDA in the observation group were significantly lower than those in the control group. The differences were statistically significant（P〈0.05 ）. Conclusion Both rhodiola and ambroxol are effective drugs used for the treatment of plateau area patients in the acute exacerbation period of chronic obstructive pulmonary diseases complicated with chronic pulmonary heart disease., The treatment effect of rhodiola is better, which can significantly improve pulmonary function index, blood gas indexes and serum indexes.