Role of phospholipids in the binding activity of vasoactive intestinal peptide receptors期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Role of phospholipids in the binding activity of vasoactive intestinal peptide receptors

Authors:	A Sarrieau N Boige M Laburthe

Institution:	(1) Equipe de Recherches sur le Mécanisme d'Action des Hormones et Neuropeptides Digestifs, Unité de Recherches de Diabétologie et d'Etudes Radio-Immunologiques des Hormones Protéiques (INSERM U. 55), Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, F-75012 Paris, (France)

Abstract:	Summary Phospholipase digestion of rat intestinal epithelial cell membranes was performed in order to study the influence of membrane phospholipids on the binding activity of VIP receptors. Phospholipases A₂ and C strougly (ED₅₀4×10^–2 and 4×10^–1 g/ml, respectively) and rapidly reduced¹²⁵I-VIP binding to membranes whereas phospholipase D was ineffective. This suggests an important role of both hydrophobic and hydrophilic groups of phospholipids on VIP receptor binding activity.This work was supported by INSERM (CRL 827017) and the Fondation pour la Recherche Médicale Française.

Keywords:	Intestinal epithelium rat VIP receptors phospholipids
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