| 非甾体类抗炎药的临床应用研究 |
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| 引用本文： | 冯乃欢,张成义.非甾体类抗炎药的临床应用研究[J].北华大学学报(自然科学版),2008,9(6). |
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| 作者姓名： | 冯乃欢 张成义 |
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| 作者单位： | 1. 吉林省吉林中西医结合医院,吉林,吉林,132012
2. 北华大学,药学院,吉林,吉林,132013 |
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| 基金项目： | 吉林市科技发展计划项目 |
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| 摘 要： | 目的阐述非甾体抗炎药物的临床应用.方法通过对国内外文献的比较分析,概述非甾体抗炎药作用机制、发展进程及发展趋势.结果非甾体抗炎药物是通过抑制花生四烯酸代谢而发挥作用,但对花生四烯酸代谢酶的选择性差异造成其严重的不良反应,使非甾体抗炎药临床应用受限.结论为了降低药物的不良反应,选择性COX-2/5-LO双重抑制剂及一氧化氮释放型非甾体抗炎药是临床用药的发展趋势.
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| 关 键 词： | 非甾体类抗炎药 环氧酶 酶抑制剂 |
Clinical Application Progress of Non-steroidal Anti-inflammatory Drugs |
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| FENG Nai-huan,ZHANG Cheng-yi.Clinical Application Progress of Non-steroidal Anti-inflammatory Drugs[J].Journal of Beihua University(Natural Science),2008,9(6). |
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| Authors: | FENG Nai-huan ZHANG Cheng-yi |
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| Institution: | FENG Nai-huan1,ZHANG Cheng-yi2 |
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| Abstract: | Objective Introduce the clinical application of non-steroidal anti-inflammatory drugs.Method By the analysis of home and abroad documents,the mechanisms,clinical application and developing trend of non-steroidal anti-inflammatory drugs are summarized.Result Non-steroidal anti-inflammatory drugs play role through inhibiting the metabolism of arachidonic acid.But the clinical application of non-steroidal anti-inflammatory drugs is limited because of the severe adverse reaction is caused by the selective difference on arachidonic acid metabolic enzymes.Conclusion In order to depress the adverse reaction,the selective COX-2/5-LO double inhibitors and nitrogen monoxidum delivery pattern non-steroidal anti-inflammatory drugs are developing trend for clinical application. |
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| Keywords: | Non-steroidal anti-inflammatory drug COX Adverse reaction |
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