| 不同类型脂肪酸对SD大鼠血清生化指标及胰岛素抵抗的影响 |
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| 引用本文： | 高青松,刘源,张涛,赵爽,王志红.不同类型脂肪酸对SD大鼠血清生化指标及胰岛素抵抗的影响[J].实验动物科学,2010,27(1):16-21. |
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| 作者姓名： | 高青松 刘源 张涛 赵爽 王志红 |
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| 作者单位： | 军事医学科学院实验动物中心,北京,100071 |
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| 摘 要： | 目的分析中链饱和脂肪酸(MC-SFA,MCF组)、长链饱和脂肪酸(LC-SFA,LCF组)、n-6多不饱和脂肪酸(n-6PUFA,SUF组)和n-3多不饱和脂肪酸(n-3PUFA,TUF组)四种脂肪酸对大鼠血清生化指标及胰岛素抵抗的影响。方法雄性SD大鼠40只随机分为5组,对照组给予普通日粮,高脂组给予脂肪热量比相同的高脂日粮。喂养10w,每18d测定空腹血糖(GLU)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、总胆固醇(TC)和血清胰岛素水平,根据胰岛素敏感性指数(ISI)=㏑1/(FPG×FINS)评定大鼠的胰岛素敏感性。结果10w后,LCF组和SUF组体重显著高于对照组和其它高脂组;LCF组和对照组血清TG显著高于其它高脂组(P0.05);LCF组血清TC显著高于对照组和其它高脂组(P0.05);高脂组血清HDL-c均显著低于对照组(P0.05)并以TUF组下降幅度最大;LCF组血清胰岛素显著高于对照组(P0.05);LCF组和TUF组ISI显著低于对照组(P0.05);各组间血糖无明显差异(P0.05)。结论不同类型脂肪酸对大鼠体重、血清生化指标及胰岛素抵抗的影响有显著差异。
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| 关 键 词： | 生化指标 胰岛素抵抗 SD大鼠 |
Effect of Different Types of Fatty Acids on Serum Biochemical Indicator and Insulin Resistance in SD Rats |
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| GAO Qing-song,LIU Yuan,ZHANG Tan,ZHAO Shuang,WANG Zhi-hong.Effect of Different Types of Fatty Acids on Serum Biochemical Indicator and Insulin Resistance in SD Rats[J].Shiyan Dongwu Kexue,2010,27(1):16-21. |
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| Authors: | GAO Qing-song LIU Yuan ZHANG Tan ZHAO Shuang WANG Zhi-hong |
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| Institution: | GAO Qing-song,LIU Yuan,ZHANG Tao,ZHAO Shuang,WANG Zhi-hong(Laboratory Animal Center of Academy of Military Medical Sciences,Beijing 100071,China) |
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| Abstract: | Objective To analyze the effect of serum biochemical indicator and insulin resistance in SD rats induced by four types fatty acids: medium-chain saturated fatty acids (MC-SFA, MCF group), long-chain saturated fatty acids (LC-SFA, LCF group), n-6 polyunsaturated fatty acids (n-6 PUFA, SUF group), and n-3 polyunsaturated fatty acids (n-3 PUFA, TUF group). Methods Normal male SD rats were fed on standard laboratory chow (8.23% of calories as fat) or isocaloric high fat diets (44.75% of calories as fat) for 10 ... |
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| Keywords: | Biochemical indicator Insulin resistance SD rats |
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