| 不同浓度掺镁透钙磷石骨水泥修复骨质疏松家兔骨缺损及BMP-2表达的研究 |
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| 引用本文： | 梁立硕,贾婉萍,方 俊,周秋娟,梁永强.不同浓度掺镁透钙磷石骨水泥修复骨质疏松家兔骨缺损及BMP-2表达的研究[J].科学技术与工程,2018,18(8). |
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| 作者姓名： | 梁立硕 贾婉萍 方 俊 周秋娟 梁永强 |
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| 作者单位： | 华北理工大学口腔医学院,华北理工大学口腔医学院,华北理工大学口腔医学院,华北理工大学口腔医学院,华北理工大学口腔医学院 |
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| 基金项目： | 河北省教育厅重点项目ZD2015016(编号：81270965) |
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| 摘 要： | 健康家兔36只,进行骨质疏松造模后随机分为空白对照组、透钙磷石组(DCPD组)、掺镁6.67%组、掺镁26.67%透钙磷石组,在家兔双侧前腿桡骨中段制作骨缺损,术后每组动物分别于4、8、12周各处死3只,观察组织切片中BMP-2表达情况与X线片显示骨缺损修复状况。免疫组化结果显示同组不同时期比较,4周时BMP-2表达最高,8周时较4周时减弱,12周时阳性表达最弱。同一时期组间比较掺镁6.67%组阳性表达最强。在骨质疏松家兔桡骨骨缺损修复中,掺镁6.67%透钙磷石组成骨效果较其他组显著,同时期组间比较BMP-2阳性表达最强。
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| 关 键 词： | BMP-2(骨形态发生蛋白-2) 骨质疏松骨缺损 掺镁透钙磷石 |
| 收稿时间： | 2017/8/26 0:00:00 |
| 修稿时间： | 2017/10/26 0:00:00 |
An experimental study of repairing Osteoporosis rabbit bone defect with different Concentrations of Magnesium - doped Brushite Bone Cements and observing expression of BMP-2 |
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| lianglishuo,jiawanpiang,fangjun,zhouqiujuan and.An experimental study of repairing Osteoporosis rabbit bone defect with different Concentrations of Magnesium - doped Brushite Bone Cements and observing expression of BMP-2[J].Science Technology and Engineering,2018,18(8). |
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| Authors: | lianglishuo jiawanpiang fangjun zhouqiujuan and |
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| Institution: | North China university of science and technology college of stomatology,North China university of science and technology college of stomatology,North China university of science and technology college of stomatology,North China university of science and technology college of stomatology, |
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| Abstract: | ] Different concentrations of magnesium calcium phosphate bone cement were used to repair bone defects in osteoporosis rabbits , observed the expression of BMP-2, investigate the optimum concentration of Magnesium - doped Brushite Bone Cements Methods: 36 healthy rabbits were randomly divided into blank control group, calcium phosphate group (group DCPD), magnesium doped 6.67% group and magnesium doped 26.67% calcium phosphate group, Bone defects were made in the middle part of both sides of the rabbit"s forelegs, After operation, 3 animals were sacrificed at 4, 8 and 12 weeks respectively. The expression of BMP-2 in the tissue sections was observed and the x-ray showed the repair of bone defects. Results: Immunohistochemistry showed the highest expression of BMP-2 at 4 weeks, 8 weeks later than 4 weeks weakened, The positive expression is weakest at 12 weeks. The most positive expression of the groupis 6.67% |
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| Keywords: | BMP - 2 (bone morphogenetic protein-2) osteoporosis bone defect magnesia permeate phosphorite |
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