Alternative splicing and genome complexity. |
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| Authors: | David Brett Heike Pospisil Juan Valcárcel Jens Reich Peer Bork |
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| Affiliation: | Max Delbrück Center for Molecular Medicine, Robert-R?ssle Strasse 10, Berlin-Buch, 13125 Germany. |
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| Abstract: | Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals. |
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